Estimation of the Pharmacokinetic Parameters of the Anti-rejection Drugs in Lung Transplantation

In this paper, we propose an algorithm to estimate the pharmacokinetic parameters of the anti-rejection drugs in lung transplantation and analyze the influencing factors. The difference equations based on the one-compartment model are constructed to obtain the pharmacokinetic parameters of each patient, including metabolic parameter and absorption parameter. Afterward, we use the stepwise regression to fit the multivariate linear equations between influencing factors and the pharmacokinetic parameters. Eight influencing factors are considered in this paper. The experimental results on the collected data show that the metabolic parameters are affected by drug sensitivity and anaerobic bacteria detection while absorption parameters are not significantly affected by the selected influencing factors.