Microfluidic Device Integrated with Deformable 3D Agpdms Beam For Blood Coagulation Monitoring

This work for the first time demonstrates blood coagulation measurement by electrical resistance sensing of a three-dimensional (3D) elastic beam deformed by flowing blood undergoing coagulation process, as enabled by a novel microfluidic strain sensor with 3D AgPDMS beam fabricated using low-cost molding process. The chip has been showcased here for the electric current change when the chip is infused with glycerol solutions at different flow rates and varied viscosities by adjusting glycerol concentrations in water. Primary testing on blood coagulation using the chip are conducted by measuring the current change when injecting the blood at increased time intervals post initiation of coagulation.