Advance in surface plasmon resonance biosensors

With the development of sensing techniques, surface plasmon resonance (SPR) biosensors are commonly used to detect various targets from small molecules to microorganisms because of their high sensitivity and selectivity, real-time analysis and label-free. The performance of SPR biosensors on both quantitative and qualitative analysis makes it play a vital role in a clinical field, food safety and environmental detection. SPR biosensor uses a special electromagnetic wave to detect targets, thus to understand how SPR sensors work is critical. Here this paper reports on how SPR biosensors work, their application and a comprehensive review of development.