Research on Influence Factors of Reverse Optimization Algorithm for Thermoseed Mediated Magnetic Induction Hyperthermia

The effectiveness of thermoseed mediated magnetic induction hyperthermia is closely related to the conformability of the hyperthermia treatment plan. The hyperthermia treatment plan system can generate the corresponding thermoseed distribution according to the size of the tumor for doctors' reference. According to the inverse optimization algorithm for thermoseed mediated magnetic induction hyperthermia, a magnetic field parameter and arrangement parameter adjustment strategy is proposed based on the temperature evaluation function. The influence of the magnetic field parameter and arrangement parameter on the optimal solution is analyzed. The effectiveness of the algorithm is verified for tumor models with spatial symmetry and complex patient tumor model. The results showed that the optimal output of thermoseed arrangement by the reverse optimization algorithm is not restricted by the shape of the tumor. It can assist clinicians in obtaining optimal thermoseed arrangement, with which the conformable temperature and thermal injury distribution for tumor inactivation is generated.