To Reduce Healthcare Workload: Identify Critical Sepsis Progression Moments through Deep Reinforcement Learning

Healthcare systems are struggling with increasing workloads that adversely affect quality of care and patient outcomes. When clinical practitioners have to make countless medical decisions, they may not always able to make them consistently or spend time on them. In this work, we formulate clinical decision making as a reinforcement learning (RL) problem and propose a human-controlled machine-assisted (HC-MA) decision making framework whereby we can simultaneously give clinical practitioners (the humans) control over the decision-making process while supporting effective decision-making. In our HC-MA framework, the role of the RL agent is to nudge clinicians only if they make suboptimal decisions at critical moments. This framework is supported by a general Critical Deep RL (Critical-DRL) approach, which uses Long-Short Term Rewards (LSTRs) and Critical Deep Q-learning Networks (CriQNs). Critical-DRL’s effectiveness has been evaluated in both a GridWorld game and real-world datasets from two medical systems: a large health system in the northeast of USA, referred as NEMed and Mayo Clinic in Rochester, Minnesota, USA for septic patient treatment. We found that our Critical-DRL approach, by which decisions are made at critical junctures, is as effective as a fully executed DRL policy and moreover, it enables us to identify the critical moments in the septic treatment process, thus greatly reducing burden on medical decision-makers by allowing them to make critical clinical decisions without negatively impacting outcomes.