Follow-up of Women Treated with LLETZ using Two Sensitive Molecular Assays

There is scientific evidence that HPV testing after therapy can predict treatment failure with significantly higher sensitivity and similar specificity compared to repeated cytology and histological status of the margins. Given the risk of recurrence of HPV infection, it is necessary to develop patient follow-up protocols, depending on the DNA / HPV status and that of cytology. We presented here 3 cases which were followed-up closely with sensitive assays after surgical intervention. The superiority of excision surgery in the case of intraepithelial cervical neoplasia is given by the success rate of the therapy. One of the most important and actual one is large loop excision of transformation zone. To predict treatment failure with significantly higher sensitivity and similar specificity compared to repeated cytology and histological status of the margins, we should repeat the testing with less invasion, especially HPV testing after therapy. The goal of these research is to establish new algorithms for successful testing and follow-up of treated women.