Chitosan/Glucantime Hydrogels as a Treatment for Cutaneous Leishmaniasis and its Preparation Method: Systematic Review

The best method for the preparation of Chitosan/Glucantime hydrogels as an administrative mechanism for the treatment of Cutaneous Leishmaniasis was identified through the systematic review of sixteen scientific articles selected by a rigorous methodology based on the PRISMA protocol that was divided into six phases: Determining eligibility criteria, search strategy, selection of articles, MMAT quality evaluation, information synthesis, and bias evaluation. After literature review, it was determined a protocol for the preparation of hydrogels that proposes to use chitosan as a biopolymer, cuminaldehyde as a crosslinking agent, and Gellan Gum spheres for Glucantime loading. This protocol provides a promising treatment for patients with cutaneous Leishmaniasis using biomaterials as drug delivery devices, contributing to the medical and biomedical fields.