The effect of electricity on the interaction between $\mathrm{A}\beta$ and lipid bilayer by AFM

There are numerous amyloid plaques deposited in specific areas in the brain of patients with Alzheimer's disease, mainly composed of Amyloid
$\beta(\mathrm{A}\beta)$
peptide. A large number of studies have shown that it plays a vital role in the process of neurotoxicity. In this study, supported lipid bilayers were used as the model system of the cell membrane. The interaction between
$\mathrm{A}\beta$
(25–35) and supported lipid bilayers with different proportions of negative charge was studied to determine the influence caused by the difference in membrane charge. An atomic force microscope was used to observe the binding of
$\mathrm{A}\beta$
(25–35) to lipid bilayer. It was found that
$\mathrm{A}\beta$
(25–35) deposited more on the negatively charged lipid bilayers, and more oligomers took shape, which caused more significant harm to the lipid bilayers. Considering that the membrane components of neurons change with age and physiological conditions, observing the differences in
$\mathrm{A}\beta$
behavior induced by membrane composition may provide more possibilities for treating of Alzheimer's disease.