Robustness of Gold Nanoparticles on Gold Film Electrode for Sweat Analysis with Miniature Sono-electroanalytical Platform

Effective strategy is urgently needed to remove the biofoulings on the surface of electrochemical electrode for developing electroanalytical sweat sensor. Decorating the electrode with nanoparticles is commonly used to improve its electrochemical activity. We propose to integrate miniature acoustic resonator within the electroanalytical microfluidic for in-situ cleaning of sweat passivation layer on electrode and study the robustness of electrodeposited gold nanoparticles on gold film electrode during acoustic cleaning process. With acoustic cleaning, sweat fully fouled electrodes can nearly recover its original electrochemical activity and meanwhile electrodeposited nanoparticles are stably remained on the electrode surface. Combining miniature acoustic resonator, electrochemical sensors, and wearable microfluidics provide an avenue for the development of wearable continuous sweat sensing for human health monitoring in molecular scale.