30MHz high-frequency contrast-enhanced ultrasound and super-resolution imaging using long-lasting microbubbles

Brain blood flow imaging has been a hot topic in ultrasound imaging in recent years. Previous studies of functional ultrasound (fUS) and super-resolution ultrasound (SRUS) mainly focus on the center frequency of 15MHz or below. The pursuit of higher temporal and spatial resolution has always been an important direction in this field. Increasing the center frequency is an important and basic method to improve the spatial resolution of ultrasound imaging. This study uses a 30MHz center frequency combined with long-lasting microbubbles to perform whole-brain blood flow imaging in baby rats and proves that ultrasound imaging can cover the whole brain depth under 30MHz.