THz TDS of SmartFilms® Loaded with Indomethacin

SmartFilms
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loaded with different amounts of indomethacin (IM) were prepared, compressed into tablets and investigated using THz TDS in transmission geometry. Corresponding physical mixtures were also prepared, transferred into tablets and investigated. Furthermore, complementary x-ray diffraction (XRD) measurements were performed. The results suggest that IM loaded in smartFilms was kept in its amorphous state for the lowest loading and recrystallized for higher loadings.