Numerical Simulation of Calcium Ion Channel Regulation by Unipolar Terahertz Field

In this paper, a mathematical physics model is set up to study the effects of THz irradiation on Ca2+ transport in the calcium channel. By means of the proposed model, the energy distribution in the three dimensional channel, the trajectories of single ion and multiple ions under THz irradiation are analyzed. It is observed firstly that the Ca2+ transmembrane transport is in the time scale of picosecond, corresponding the spectrum concentrated in the THz range. By means of Brownian dynamics (BD) simulations, we demonstrate greatly enhanced permeation of the calcium channel in reaction to an external THz wave. With the amplitude and frequency increases, the rate of ion transport across the channel increases significantly.