Graphene-based liquid gated field-effect transistor for label-free detection of DNA hybridization

The low noise and the high transconductance of graphene field-effect transistor uplift it as an auspicious candidate for different standard biological applications. Recently, a reliable determination of DNA hybridization's binding kinetics plays an essential role in biological systems, personalization and precision medicine. Here, we demonstrate a field-effect transistor based on a single CVD-grown graphene layer for label-free DNA hybridization detection. The developed biosensor displays a 7 mV/dec sensitivity in a wide dynamic range spanning 7 orders of magnitude with a detection limit of 15 fM, and exhibited a good selectivity against the non-complementary target. Bio-recognition events result in a negative gate voltage shift of the graphene Dirac point.