Multifunctional magnetic particle-based nanocarriers with easily modifiable surface for in vivo transfection

Here we show a new multifunctional optically active magnetic particle-based DNA nanocarrier for effective in vivo transfection. We demonstrate successful gene expression of luminescent protein in mouse lungs and spleen. The biodistribution of the nanocarriers was visualized by magnetic and fluorescent methods and signal from the nanoparticles were observed in lungs, spleen and liver.