Acoustic detection of nanoparticle structural stability in physiological media after their laser irradiation

Here we present a method of photoacoustic detection of nanoparticle degradation. To validate the method, we used biodegradable silicium nanoparticles, which can absorb light in the Uv-Vis region and generate acoustic waves in response. The photoacoustic method allows measuring kinetic of their degradation in real-time with high limit of detection up to a hundred ng of particles.