Microbubble-Assisted Concentration and Ultrasensitive Detection of Biomolecules Using Plasmonic Chiral Metamaterials

We achieve the ultrasensitive chiral detection of metabolites at picomolar level. The ultra-high sensitivity is enabled by microbubble-assisted accumulation of chiral molecules at the electromagnetic hot-spots of plasmonic chiral metamaterials, which could potentially provide first-line screening to identify diabetes case.