Imaging of Caenorhabditis elegans by spectrally encoded confocal microscopy

In this study, spectrally encoded confocal microscopy (SECM), a high-speed form of reflectance confocal imaging, is utilized for high resolution imaging of Caenorhabditis elegans (C. elegans). Developed system incorporates near-infrared illumination at 1310nm and can offer confocal imaging at 147KHz line rate with lateral resolution of ~2μm. Our preliminary results suggest ability of the system in resolving various organs of C elegans at high throughput which is key for studying disease models in organisms in biological studies.