Development of a SERS-based Diagnostic Method for Coronary Heart Disease with Urine

A rapid and noninvasive method based on surface-enhanced Raman spectroscopy (SERS) was developed to diagnose blockage degree of coronary arteries prospectively by detecting platelet-derived growth factor-BB (PDGF-BB) in urine in our previous research. In this work, 3102 cases over 45 years old from the general population were investigated with this method. It was found that 11% of the investigated cases were with different degrees of blockage. This diagnostic method can be potentially employed to reveal the coronary arterial blockage degree of patients with coronary heart disease and to predict the morbidity of the atherosclerosis in general population.