Design and fabrication of CMOS-based neural probes for large-scale electrophysiology

Large-scale neural recording requires more advanced and denser brain interfaces. This paper describes the design and fabrication of the CMOS-based Neuropixels neural probe, which integrates a high-density micro-electrode array and a high channel count to enable large-scale electrophysiology in small animals. Miniaturization and scalability aspects are also discussed here.