Ultrasonic Surface Acoustic Wave platform for targeted pulmonary delivery of nano drug vehicles

This work shows a new method that employs surface acoustic waves (SAW) to form liposomes and simultaneously create a narrow distribution of inhalable aerosols that falls within the ideal respirable range size. The main advantage of using SAW is that, in one step, we can control the aerosols droplet size distribution and simultaneously create drug carriers of biological and active compounds, which are often degraded in alternative nebulisation methods. To corroborate the effectiveness of the proposed SAW nebulisation platform, nucleic acids were nebulised and deliver to lung cancer cells.