Ultra-Thin Magnetic Micropump for On-Demand Drug Delivery

In this paper, we propose an ultra-thin magnetic micropump capable of on-demand drug delivery for ocular diseases. The proposed ultra-thin magnetic micropump is less than 500 μm thick and can be easily embedded in contact lens or periocular implant. Precise on-demand drug release was realized by the deflection of the magnetic membrane assembly according to the external magnetic field, and the membrane assembly consists of a thin elastic PDMS membrane and a cylindrical magnetic nanoparticle-PDMS composite block. Additionally, micro check valve composed of two PDMS layers was integrated into the micropump to realize one-directional drug delivery and prevent undesired drug diffusion.