Two-Dimensional Immersive Cohort Analysis Supporting Personalised Medical Treatment

Genomic data are large and complex which are challenges to visualize them effectively on ordinary screens due to the limited display spaces. Large and high resolution displays could enable the capability to show more information at once for better comprehension from the visualization. This paper presents a two-dimensional interactive visualization system and supporting algorithm for multi-dimensional large genomic data analysis that can be used in both ordinary displays or immersive environments. We provide both view of the entire patient cohort in the similarity space and the genomic details currently for comparison among the patients. Through the similarity space and on the selected genes of interest, we are able to perceive the genetic similarity throughout the cohort. From the linked heat map visualisation of the selected genes, we apply hierarchical clustering on both the horizontal and vertical axes to group together the genetically similar patients. We demonstrate the effectiveness of the visualization with two case studies on pediatric cancer patients suffering from Acute Lymphoblastic Leukemia (ALL) and from Rhabdomyosarcoma (RMS).