Central Blood Pressure Waves Assessment: A Validation Study of Non-Invasive Aortic Pressure Measurement in Human Beings

Measurement of central systolic (aortic) blood pressure has been shown to provide the more precise information to evaluate target organ assessment. However, non-invasive central blood pressure measurement procedures are still under analysis. The aim of this study was to compare pressure waveforms invasively obtained in the aorta, with the corresponding waveforms non-invasively recorded using a Mobil-O-Graph device. In this research were included 20 subjects submitted for invasive coronary evaluations. They were 10 males (68 ±12 y. o., BMI: 27.4 ±4.6 Kg/m2) and 10 females (77 ±8 y. o., BMI: 28.5 ±5.3 Kg/m2). During the invasive aortic pressure recording a synchronized non-invasive Mobil O Graph acquisition beat by beat was performed. Both blood pressure waves were digitized and stored for sub-sequent analysis and calculations. A computerized inter-polation procedure was developed in our laboratory to compare invasive and non-invasive central blood pressure waves. A significant correlation between Mobil O Graph central blood pressure measurements and the corresponding invasive values, was found in men (r$\lt $0.89) and women (r$\lt $0.917). However, in both genders, the slope of the regression lines (Men: y = 0.7673x + 16.301; Women: y = 0.7874 x} + 22.008) was lesser than 1. In this research, it was shown a high correlation, either in men, women or the whole population, between invasive central blood pressure values and those measured with the Mobil O Graph device. However, a sub estimation of Mobil O Graph central blood pressure values was observed.