Characterization and Clinical Serum Test of a Molecular Imprinted Polymer (MIP)-Based Cardiac Troponin T Sensing Electrode for Patient Monitoring Applications

This article presents a cardiac troponin T (cTnT) sensing electrode fabricated using a molecular imprinted polymer (MIP) for clinical studies for the first time. The MIP-based sensing electrode is an electrochemically polymerized o-phenylenediamine film, which can detect cTnT concentrations ranging from 0.017 to 10 ng/mL in 15 min and can be reused more than six times without any performance degradation. There are no size and thickness effects on the sensing electrode, showing its high potential to be a cost-effective cTnT sensor for clinical applications. Clinical blood serum testing results show that the electrode can provide the same cTnT detection levels as the levels measured using the existing electrochemiluminescence method in a tertiary university-affiliated hospital.