Preparation of Vitamin C doped polymers for physical characteristics using electrospinning process

Rapid drug release has become more important for the drug delivery system due to its rapid release, bioavailability and enhanced drug solubility. With a solid tablet an d a thin film as the design to enhance its rapid-release characteristics, to achieve this feature requires a highly porous network. Molding with traditional methods, such as rapid freezing, 3D printing, and sintering. It is almost impossible to prepare fibers with diameters less than 1 μm. The electrospinning technology is simple in its production process and inc reases the surface area, high length, uniform diameter and diverse components of the nano-fiber. In this study, three types of polymers, including Polyvinylpyrrolidone (PVP), Polysulfone (PES) and Polystyrene (PS), were mixed with Dimethylformamide (DMF) to form a precursor solution, which is used to prepare a large number of nanofibers through electrospinning method. Then with electrospinning method with vitamin C as the target molecule, nonwoven nanofibers were prepared. The experiment was carri ed out under the manipulation of field emission electron microscopy (FE-SEM), thermogravimetric loss analyzer (TGA), thermomechanical analyzer (TMA) and water droplet angle tester to analyze the properties of nanofibers and to explore the drug release. After placing in the air for different durations, because of the water vapor and the their own nature of the nanofiber that enable itself to shrink, the nanofiber would lose its nano-nature through a long time of shrinking, which led to the deceleration of dissolution, and thus made it easier to contro l its release rate
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