MoS2-Based Dual-Gate mosfet as Ultrasensitive SARs-CoV-2 Biosensor for Rapid Screening of Respiratory Syndrome

In this letter, an attempt for rapid detection of biomarkers for SARs-CoV-2 virus is initiated for the first time, employing MoS
₂₌
based dual-gate
mosfet
with embedded nanogap in the gate dielectric. Based on the spike, envelope, and DNA proteins of the virus, a deep analysis of the device performance in terms of transfer characteristics
I
_on
/I
_off
ratio is performed using SILVACO ATLAS TCAD by considering the dielectric constant equivalent of the virus proteins as κ = 4,10,12 and with variation of DNA charge densities as −2 × 10
¹²
Ccm
⁻²
to +2 × 10
¹²
Ccm
⁻²
. The threshold voltage (V
_th
) is eventually extracted and is used as the detection metric to evaluate the sensing ability of the device exhibiting superior V
_th
sensitivity as high as 100 mV as compared to some of the existing models. Results also reveal a high dependency of the sensitivity on the bioelement configuration within the nanogap and the channel material.