1. Introduction
Europe's logistics market is one of the most important economic factors, with a market volume of billion in 2010 [14]. The largest part of the market volume is represented by transportation and warehousing, with a share of 42% and 26%, respectively. The increasing market competition and the service focus of customers force courier-express-parcel service providers to re-evaluate and to continuously improve their networks. Worldwide, the necessity to improve the service quality is rapidly growing. Especially time aspects, such as delivery to the destination within the next day, are key performance indicators for service quality. To reduce costs and increase service quality, facility location and route planning strategies are crucial choices. Both of the underlying basic problems - the facility location problem (FLP) and the vehicle routing problem (VRP) – have been studied and solved intensively over the last decades as individual models. To reduce the complexity of the combined problem, both problems are usually tackled independently and in a sequential manner (locate first and route second). In particular, aspects of future route plans are neglected during the strategical location planning level of most distribution systems, and only approximated. This approximation needs, however, a priori knowledge of transport services, and research has shown that this strategy often leads to suboptimal solutions, as shown by Salhi and Rand [24]. Exact methods for the capacitated location-routing problem include column generation [1] and branch-and-cut [3]. Although some instances with 100 customers remain unsolved, these methods are able to solve instances with up to 200 customers. However, real problems consist of large-size instances with up to 1000 customers and hundreds of potential depots. To handle this kind of instance, several metaheuristics have been proposed (e.g. [9], [18], [20], [21], [26], and [28]). In recent years, the attention has increased, and many of the published works deal with real problems. For example, military [17], the paper industry [22], and postal logistics (e.g. [5], [12], and [27]) to name just a few. An overview is provided by Nagy and Salhi [19].