A Flexible Implantable Polyimide Catheter Device for Targeted Treatment of Cardiovascular Diseases by Aggregating Magnetic Nanoparticles

This article presents a flexible implantable device fabricated on a polyimide (PI) catheter for targeted treatment of cardiovascular diseases. The copper (Cu) microcoil was fabricated on a PI catheter surface using the rotated UV lithography system and surrounding electroplating technology. The simulation on the magnetic fields generated from the Cu microcoil with 0.2 A current and the driving force analysis on magnetic nanoparticles (MNPs) were conducted. The results demonstrated the precise control of MNPs motions within the magnetic fields generated from the Cu microcoil fabricated on the PI surface. The maximum temperature that increased from the magnetized Cu microcoil was 2 °C at room temperature, suggesting no induced hyperthermia. Moreover, the electrical performance of Cu microcoil was excellently stable in a variety of environments, such as wet, dry, and mechanical fatigue conditions.
In vivo
tests displayed great biocompatibility of the fabricated device within the carotid artery of a rat model. The directional assembly of MNPs can be achieved by a Cu microcoil fabricated on the surface of a PI catheter. The fabricated device shows notable advantages in promoting the targeted therapeutic strategy of cardiovascular diseases.