Leveraging Machine Learning to Identify Synergistic Drug Combinations for Effective Cancer Treatment

The potential of drug combinations to treat and overcome medication resistance complex genetic diseases is evident. Synergistic drug combinations offer a promising way to enhance drug therapy efficacy and reduce the required medication dosage. However, developing effective combination medication therapies with synergistic effects has been challenging, despite numerous ongoing clinical investigations. Current models and approaches to detect medication synergy outlined in the literature lack the expected consistency in outcomes. to better comprehend the impact of particular medication combinations, it is essential to be familiar with the vocabulary used to describe synergy. In this study, a combinational drug screen is utilized to identify useful features for locating synergistic or efficient drug combinations. The feature selection algorithm (Boruta) helps select the most relevant features, and machine learning models are then trained using the selected feature dataset. Performance assessment metrics like sensitivity, accuracy, and specificity are used to compare the trained models, and the Random Forest model stands out for its significantly better performance compared to other models.