Advancement in Breast Cancer Diagnosis: Detecting CA15-3 Antigen Using Surface Plasmon Resonance in Photonic Crystal Fiber

This manuscript introduces a surface plasmon resonance sensor designed for the highly sensitive detection of the biomarker CA15-3, crucial for diagnosing Breast cancer. The sensor is based on an anisotropic dual-core, double-side-polished photonic crystal fiber. Analyzing analytes with refractive indices (RI) ranging from 1.33 to 1.36 RIU, the biosensor exhibits significant potential. The numerical analysis of sensing parameters reveals a peak wavelength sensitivity of 42,000 nm/RIU for x-polarization when employing the wavelength interrogation technique. The sensor demonstrates a maximum amplitude sensitivity of 105 RIU
^-1
and achieves a remarkable sensor resolution of 3.6225 × 10–
⁶
RIU.