Effect of Action Potential on Axoplasmic Flow in Hippocampal Neurons

Action Potential (AP) in neural cells is accompanied by displacement and pressure waves. Effect of AP on fluid velocity filed of axoplasm is pivotal in studying physical basis of neurophysiological phenomena, such as axonal transport and tau propagation in neural cells. The goal is to provide a basis for future studies on axonal transport and in this work a report is presented on the effects of AP on fluid velocity resulted from a fluid-solid interaction (FSI) computational simulation. Here it is shown that there exists an axoplasmic flow induced by AP with a magnitude in range of tenths to tens of micrometers per second and it’s behavior is proven to be a matter of interest for future studies.