Detection and Visualization of Metabolic Pathway Activity Based on Immunohistochemistry

The paper describes an approach of platform development for the visualization of metabolic pathways based on enzyme expression data in cancer samples. The input of the application is immunohistochemically measured expression data of metabolic enzymes specifically given for the examined cancer sample. Immunohistochemical evaluation happens according to the H-score and the Shannon diversity index calculated from the given expression data. The platform uses scalable vector graphics and microservices, implemented mostly in Java and TypeScript.