A Continuous Blood Glucose Monitoring Front End IC Design with Large Input Range

This work presents a method that allows continuous blood glucose monitoring and provides a complete circuit that can continuously process a larger range of input currents for the more sensitive needle electrodes with electrodeposition technology. The circuit uses switched-capacitor to differentially process the two parts of the signals from target electrode and background reference electrode, thus greatly reducing the interference current generated by the complex blood environment of the human body. This work also makes full use of the adjustable characteristics of the circuit by adjusting the frequency of sampling and capacitance size of the circuit for different input current ranges, which maintains the excellent performance of the circuit. The monitor and readout IC proposed in this paper reduces the overall power consumption to 0.98 mW under 3.3 V supply voltage, while it extends the input current range to more than $48 \mu \mathrm{A}$ with minimum input-referred noise of 16 pArms.