Electrochemical detection of ciprofloxacin using Cu-Ag core-shell nanoparticles modified screen-printed electrode

A new sensitive, efficient, and cheap electrochemical sensor for ciprofloxacin detection was developed. Simple chemical reduction was used to synthesize Cu-Ag core-shell nanoparticles (Cu@Ag NPs). Cu@Ag NPs were characterized using UV-vis then modified onto screen-printed electrode (SPE) surface by the drop-casting method. Square-wave voltammetry (SWV) was used to study the response of ciprofloxacin towards the modified electrode. Electrochemical measurements were carried out using phosphate buffer solution pH 7. Under optimized experimental conditions, the developed electrodes exhibited a linear range of 30-100 μM. The Cu@Ag/SPE has good sensitivity with a low detection limit of 0.213 μM. Analysis on real samples tested in artificial urine. The recovery of the analyte in the real sample was 98.82%. This shows that the developed electrode can be used for fast, easy, and sensitive detection of ciprofloxacin in urine samples.