Dynamic transitions of functional brain connectivity during a working memory task

Working memory is a cognitive system that temporarily stores and manipulates information via attention. Although brain activity patterns related to working memory have been extensively studied, little is known about how the brain connectome organization dynamically changes while performing working memory tasks. Here, we systematically investigated dynamic changes in functional brain connectivity during a working memory task. We found that functional connectivity in the medial frontal and orbitofrontal cortices and the precuneus showed differences during the transitions between the rest and task. Our results provide topographic patterns of dynamic functional connectivity during the working memory tasks.Clinical Relevance— This study may provide macroscale topography related to working memory and foster establishing memory-related brain mechanisms, which could be applied to clinical neuroscience.