Weighted Compensation of Raise-to-the-Power Method for Coordinate Reconstruction in Prism-PET with Interleaved Multiplexing Readout

In positron emission tomography (PET) design, signal multiplexing is an important technique to reduce the number of readout channels and to lower the scanner’s complexity and cost. Accurate reconstruction of gamma-ray events in the flood histogram is crucial for further image reconstruction. This paper proposes a novel algorithm for coordinate reconstruction in the Prism-PET, which combines the conventional raise-to-the-power (RTP) method with the deterministic light-sharing pattern of the Prism-PET detector module with the interleaved multiplexing scheme. The resulting flood histograms demonstrate perfect crystal identification with no decoding errors, preserving the high-resolution capabilities of the Prism-PET detector module with multiplexed readout.