Smartphone Fundus Photography Enhancement for Retinopathy of Prematurity Disease Diagnosis Using Deep Learning

Retinopathy of Prematurity (ROP) is the highest cause of childhood blindness globally with babies born preterm having a higher probability of contracting the disease. The disease diagnosis remains an economic burden to many countries, lack of enough ophthalmologists for the disease diagnosis coupled with non-existent national screening guidelines still remains a challenge. To diagnose the disease, a fundus photography is conducted, printout images are analyzed to determine the presence or absence of the disease. With the increase in the development of smartphones having advanced image capturing and processing features, the utilization of smartphones to capture retina image for disease diagnosis is becoming a common trend. For regions where ophthalmologists are few and/or for low resource regions with few or no retina capturing equipment, the use of smartphones to capture retina images for retina diseases is an effective method. This, however, is challenged: different smartphones produce images of different resolutions; some images are darker others lighter and with different resolution. A smartphone retina image capturing has a smaller field of view ranging between 450–900 which is a major limitation. A lens to support a bigger view can be combined with this approach to provide a wide view of 1300. This enlargement however distorts the image quality and may result in losing some image features. To overcome these challenges, this work develops an improved U-Net model to preprocess images captured using smartphones for ROP disease diagnosis. Our focus is to determine the presence or absence of the disease from smartphone captured images. Because the images are captured under a smaller field of view (FOV), we develop an improved U-Net model by adding patches to enhance image circumference and extract all features from the image and use the extracted features to train a U-Net model for the disease diagnosis. The model results outperformed similar recent developments with an AUC of 0.9890, F1 Score of 0.8216, Accuracy of 0.9807, Sensitivity of 0.8550 and Specificity of 0.8340 on testing results.