Directional Neural Connectivity during Robot Mirror Therapy in Patients with Stroke

This study explored directional connectivity networks during hand movement training in stroke patients using 8 conditions combining mirror therapy, robot-assisted bimanual therapy, and object manipulation. The findings revealed that mirror therapy and robot-assisted bimanual therapy decreased interhemispheric inward connectivity to the affected motor cortex in the left-hand paralyzed patient, reducing inhibitory control. Conversely, these interventions increased interhemispheric inward connectivity in the right-hand paralyzed patient, suggesting enhanced excitatory connectivity. The results emphasized the influence of neurorehabilitation methods, hemiparesis severity, and affected side on interhemispheric connectivity. Further research is needed to develop personalized rehabilitation strategies based on directional connectivity measures.