Researching of Biologically Active Polymeric Hydrogel Transdermal Nanomaterial's Modification by Humic Acid

Biologically active polymer hydrogel transdermal nanomaterial's based on gelatin, hydroxypropyl cellulose, sodium alginate, modified by humic acids, were designed and researched. It has been found that effective processes for receiving biologically active polymer hydrogel transdermal nanomaterial's based on gelatin, hydroxypropyl cellulose and sodium alginate can be carried out in different humic acids concentration values while achieving an increase in hydrogel polymers structuring processes. In this article, effective 3D printing technology of biologically active polymeric hydrogel transdermal nanomaterial's microneedles patches based on gelatin, hydroxypropyl methylcellulose and sodium alginate, modified by humic acids, were researched. Biologically active polymeric transdermal hydrogel nanomaterial's microneedles patches were produced using a micromolding technique where an FDM 3D printer was used to print the master mold. Form modeling was done in Autodesk's Fusion 360. The resulting 3D model was processed by a slicer to receive a file with commands for a 3D printer. It is shown that the application of new biologically active polymeric hydrogel transdermal nanomaterial's microneedles patches based gelatin, hydroxypropyl methylcellulose and sodium alginate modified by humic acids allows improving the skin moisture-lipid balance.