Non-invasive Monitoring of Vital Signals and Autonomic Nervous System During Pharmacological Research

Rapid non-invasive monitoring of mouse indicators are important for pharmaceutical and pharmacological research. In this paper, a radio frequency (RF) sensing system that can monitor vital signals and autonomic nervous system (ANS) non-invasively is proposed. The system consists of a software-defined radio (SDR) and a test platform. The operational frequency is 1.1 GHz. We monitored the vital signs of the C57BL/6 mouse which is injected with 1% Pentobarbital sodium. The system obtained its heart rate (HR), breathing rate (BR) and heart rate variability (HRV). And the HRV is further analyzed to represent autonomic nervous system activities.