Mean-Field Model of Tripartite Synapse with Infected Glial Cells

This study presents a mathematical model that combines the average activity of excitatory neurons, neuron-astrocyte interactions, and virus concentration dynamics to examine the effects of virus infection on bursting generation. Our results demonstrate that astrocyte infection hinders gliotransmitter release, potentially leading to the termination of rhythmogenesis. Disruptions in brain rhythmogenesis can result in cognitive function disorders, including memory impairment. The proposed model serves as a crucial theoretical tool for investigating the underlying mechanisms of rhythmogenesis disruption.