A study of the characteristics of Skin Impedance Models based on the simulation of models

Transdermal drug delivery (TDD) through human skin has been established using a variety of active and passive methods. The inability to easily quantify or estimate the amount of medicine administered is one drawback of TDD. For electrically controlled drug delivery methods like iontophoresis, electroporation, etc., this presents a significant challenge. It has been demonstrated that the amount of medication absorbed is correlated with the electrical impedance of the skin. An electrical equivalent circuit can simulate the intricate structure of human skin to determine its frequency-dependent impedance. The modelling of human skin can be done in a number of ways. These models are a combination of R and C components and are modelled to represent biological skin qualities as well as the physiological stratification of skin. To comprehend the differences between the models in terms of impedance spectrum at various frequencies, the transfer functions (TF) of the models are plotted and compared in this work. This investigation reveals the detailed differences between existing models and will motivate the creation of new ones that more accurately reflect the impedance of human skin.