I. Introduction
Limitations in the ability of current breast transmission imaging techniques have resulted in high false-positive rates for breast lesion malignancy and false negative rates of between 10–20% in patients with dense fibroglandular tissue [1]. Various modalities have been applied in unique ways to 3D breast transmission imaging to attempt to improve diagnosis. Some groups are investigating dedicated x-ray computed mammotomography (CmT) alone [2], [3], and others have proposed CmT and emission imaging [4], [5]. Tomographic techniques promise improved contrast resolution versus dual view mammography through the inherent removal of overlying tissues but with an added challenge of limiting patient dose where large numbers of projection images are required. It has been predicted that CmT can potentially be performed at or below dose levels of dual view mammography [2], [3].